News overview
All news at a glance.
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Image-activated cell sortingIt was a pleasure to contribute to this review highlighting the power of image activated cell sorting.
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Next generation genetic screens in kinetoplastidsThe state of the art and future applications of image-based and single-cell sequencing based genetic screens in kinetoplastids.
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Genomic Determinants of Antigen Expression Hierarchy in African TrypanosomesA highly sensitive single-cell RNA sequencing approach sheds light on the VSG-selection mechanisms in Trypanosoma brucei.
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Micro-C reveals T. brucei genome organisation at high resolutionInter-chromosomal transcription hubs shape the 3D genome architecture of African trypanosomes
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RNA processing and stability contribute to gene expressionWe implemented SLAM-seq and TT-seq in African trypanosomes to study RNA maturation
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Tissue spaces are reservoirs of antigenic diversity for trypanosomesSleeping sickness: pathogens play hide-and-seek. Great collaboration with the Mugnier lab
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Smoother: on-the-fly processing of interactome data using prefix sumsCheck out our latest manuscript to learn how Hi-C and RADICL-seq data can be processed and visualized using an interactive interface
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Decoding the impact of nuclear organization on antigenic variation in parasites.Our review describes the importance of 3D genome architecture in the regulation of antigen expression.
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DFG funding to study antigenic variation in Uganda and KenyaApplication for PhD position opens soon.
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Our most complete and most accurate 427 Lister diploid genome assemblyThe peer-reviewed version is now online
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The CRC Chromatin Dynamics received funding for another 4 yearsWe still have one open PhD student position - apply now
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Spatial integration of transcription and splicing in a dedicated compartment sustains monogenic antigen expressionOur new manuscript has been published by Nature Microbiology.
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Can RNA-processing hotspots serve as post-transcriptional enhancers?Our new manuscript is now on bioRxiv